AIM: The main goal of this study is to identify profiles of mothers based on the level of maternal self-confidence, and symptoms of depression and anxiety. Moreover, the objective is to evaluate how these profiles differ regarding perinatal, parental, and health variables. METHODS: A prospective study was performed from 2020 to 2021 with 179 postpartum mothers of infants who had participated in a longitudinal study (The Cope Study) during pregnancy. The survey included sociodemographic, prenatal, parental, and health details and standardized psychological measures: MCQ, PHQ-2, and GAD-7. FINDINGS: The cluster analyses revealed two profiles of mothers. The first was described as the "adaptive profile of mothers," with high self-confidence and low rates of depression and anxiety (60, 3 %), and the second was defined as the "maladaptive profile of mothers," with low maternal self-confidence and high rates of depression and anxiety (39.7 %). In the "maladaptive profile of mothers" group, more women experienced higher stress, declared fewer health-promoting behaviors, assessed their health as worse, received less support from their families, had labor induction, and had low birth satisfaction. CONCLUSION: These results support the importance of early and multilevel psychological screening to understand the experience of infants' mothers and to develop targeted and increasingly personalized interventions.