Nutrient starvation is a critical consequence of heavy metal toxicity, severely impacting plant health and productivity. This issue arises from various sources, including industrial activities, mining, agricultural practices, and natural processes, leading to the accumulation of metals such as aluminum (Al), arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg), and nickel (Ni) in soil and water. Heavy metal exposure disrupts key physiological processes, particularly nutrient uptake and transport, resulting in nutrient imbalances within the plant. Essential nutrients are often unavailable or improperly absorbed due to metal chelation and interference with transporter functions, exacerbating nutrient deficiencies. This nutrient starvation, coupled with oxidative stress induced by heavy metals, manifests in impaired photosynthesis, stunted growth, and reduced crop yields. This review presents important insights into the molecular mechanisms driving nutrient deprivation in plants exposed to heavy metals, emphasizing the roles of transporters, transcription factors, and signaling pathways. It also examines the physiological and biochemical effects, such as chlorosis, necrosis, and altered metabolic activities. Lastly, we explore strategies to mitigate heavy metal-induced nutrient starvation, including phytoremediation, soil amendments, genetic approaches, and microbial interventions, offering insights for enhancing plant resilience in contaminated soils.