OBJECTIVES: This study seeks to outline the epidemiological patterns and quality of care indicators of ischemic stroke in Colombia. It serves as a pioneering effort, offering crucial national-level insights to inform evidence-based stroke policies in Colombia. MATERIALS AND METHODS: Using data from the Registry of Stroke Care-Quality (RES-Q) spanning the years 2017 to 2021, a multicenter descriptive study was conducted in Colombia. A survival analysis using Kaplan-Meier curves was planned for the time from symptom onset to hospital arrival, hospital stay and mortality, stratified by pre-established geographic regions. RESULTS: A total of 7,963 patients were included in 4 geographic regions: Amazon, Andean, Caribbean and Pacific. The main data provider was the Andean region with 6,402 patients (80.3 %). 49 % were women. The median age was 72 years (IQR 61-81). The NIHSS scale was a median of 7 IQR (3-15). 14.5 % (994) received intravenous thrombolysis therapy. The door to needle time was 53 min IQR (36-70). 53 % were hospitalized in a standard bed, 41 % in intensive care/stroke unit. 33.4 % patients had a Rankin score at discharge between 0-2. CONCLUSION: First study conducted using RES-Q data at the national level in Colombia. A reduction of door-to-needle times by at least 50 % compared to historical levels is evident. Low reperfusion rates persist. Secondary prevention measures are needed with the implementation of national stroke policies.