Human placental mesenchymal stem cells regulate the antioxidant capacity of CD8

• Tác giả: Xiying Luan, Xiaolin Ma, Yunhua Wu, Wei Yan, Hengchao Zhang, Jiashen Zhang, Yaxuan Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Molecular immunology , 2025
• Bộ sưu tập: NCBI
• ID: 731658

Tóm tắt

 Graft-versus-host disease (GVHD) constitutes a severe complication that occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT), significantly reducing the survival rate of patients. Mesenchymal stem cells (MSCs) are capable of ameliorating the tissue damage caused by GVHD through exerting immunosuppressive effects
  however, the relevant mechanisms require further investigation. This study used a GVHD mouse model to explore the therapeutic effects and mechanisms of human placental mesenchymal stem cells (hPMSCs) in mitigating GVHD-induced liver injury. The findings indicated that hPMSCs reduced the proportion of CD8