SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis.

• Tác giả: Venetia Bazioti, Laura Bongiovanni, Hendrik Buikema, Azuwerus van Buiten, Alain de Bruin, Igle Jan de Jong, Simon M De Neck, Leo E Deelman, Anouk G Groenen, Benedek Halmos, Robert H Henning, Nicolette C A Huijkman, Helle F Jørgensen, Niels J Kloosterhuis, Mirjam H Koster, Folkert Kuipers, Anouk M La Rose, Miriam Langelaar-Makkinje, Daisey Methorst, Dalibor Nakládal, Elisabeth M Schouten, Judith C Sluimer, Marius C van den Heuvel, Marit Westerterp
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Circulation research , 2025
• Bộ sưu tập: NCBI
• ID: 731733

Tóm tắt

BACKGROUND: Smooth muscle cells (SMCs) regulate blood flow distribution via vasoconstriction mediated by α-ARs (α-adrenergic receptors). Plasma membrane cholesterol accumulation affects α METHODS: We generated mice with SMC-specific RESULTS: Combined CONCLUSIONS: We uncover a new role of SMC cholesterol efflux pathways in suppressing α