Sleep disturbances in children with ADHD on methylphenidate monotherapy: The role of dysregulation profile.

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Tác giả: Barbara D'Aiello, Pietro De Rossi, Ludovica Gessi, Deny Menghini, Stefano Vicari

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Netherlands : Sleep medicine , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 731956

Dysregulation profile has been associated with Attention-Deficit/Hyperactivity Disorder (ADHD) in children and adolescents, influencing its progression, outcomes, and potentially the response to treatment with methylphenidate, a commonly prescribed stimulant medication. Sleep disturbances are also closely linked to ADHD, as they significantly impact clinical outcomes and overall functioning, with variable responses to methylphenidate treatment. This study aimed to investigate whether methylphenidate improves sleep disturbances in children with ADHD and whether the presence of dysregulation profile negatively predicts this improvement. To explore this, we examined the role of baseline dysregulation profile (assessed with the Child Behavior Checklist), age, ADHD symptom severity (assessed with SNAP-IV scores), and functional impairment (assessed with ABAS-II scores) as potential predictors of changes in sleep disturbances (assessed with SDSC scores) following six months of methylphenidate monotherapy. A total of 115 participants (98 males) aged 6-17 years (mean age 10.32 ± 2.78 years) were included in the study. A hierarchical linear regression model was used to determine whether these baseline factors could predict changes in sleep disturbances, while accounting for initial sleep severity. The results showed that the presence of dysregulation profile at baseline was associated with higher sleep disturbances after treatment. While ADHD severity at baseline was associated with sleep disturbances at follow-up, it did not demonstrate any significant predictive value for sleep outcomes over time. In conclusion, dysregulation profile may act as a negative predictor of sleep outcomes following methylphenidate treatment. These findings highlight the importance of systematically assessing dysregulation profile before starting treatment. Future research with larger sample sizes and longer follow-up periods is needed to confirm these results and identify additional factors that contribute to sleep disturbances in children and adolescents with ADHD.
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