Monotropein resists atherosclerosis by reducing inflammation, oxidative stress, and abnormal proliferation and migration of vascular smooth muscle cells.

• Tác giả: Hongliang Li, Jingyan Liang, Tan Ma, Won Sun Park, Jiping Tian, Bofan Wang, Bingqian Ye, Yiwen Zha, Shuying Zheng, Wenwen Zhuang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 633.14 *Rye
• Thông tin xuất bản: Korea (South) : The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 732448
• Chủ đề: 1. Monotropein; 2. Resists; 3. Atherosclerosis

Tóm tắt

Monotropein is a compound classified into iridoid which is found in herbaceous plants Morindae officinalis. It possesses anti-inflammatory, antioxidant, and anti-osteoarthritic activities. Previous study indicates that monotropein may have the potential to combat cardiovascular disease, although the related mechanism remains unclear. In this study, we constructed the model of atherosclerosis by oxidized low density lipoprotein-induced vascular smooth muscle cells and LDLR