OBJECTIVES: Deuterium ( MATERIALS AND METHODS: Six healthy volunteers (2f/4m) were scanned after oral administration of 0.8 g/kg [6,6']- RESULTS: The bSSFP-CRT approach achieved SNRs that were up to 3-fold higher than conventional spoiled FID-CRT CONCLUSION: In this study we successfully implemented a balanced steady state free precession (bSSFP) acquisition scheme for dynamic whole-brain human DMI at 7T. A 3-fold SNR increase compared to conventional spoiled acquisition allowed us to double the spatial resolution achieved using conventional FID-CRT DMI. Systemic continuous glucose measurements, combined with dynamic DMI, demonstrate significant potential for clinical applications. This could help to improve our understanding of brain glucose metabolism by linking it to time-resolved peripheral glucose levels. Importantly, these measurements are conducted in a minimally invasive and physiological manner.