Attenuated adenosine mediated immune-dampening increases natural killer cell activity in early age-related macular degeneration.

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Tác giả: Vishnu Suresh Babu, Koushik Chakrabarty, Jayasree Debnath, Vrushali Deshpande, Arkasubhra Ghosh, Sayan Ghosh, James T Handa, Stacey Hose, J Jiang Qian, Santhosh Gopi Krishna Gadde, Archana Padmanabhan Nair, Machiraju Praveen, Karthik Raja, Ganesh Ram Sahu, Aishwarya Saxena, Swaminathan Sethu, Naren Shetty, Rohit Shetty, Debasish Sinha, M B Thirumalesh, Tanuja Arun Vaidya, Ying Xin

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 732486

Thêm vào giỏ Liên kết toàn văn

Non-exudative age-related macular degeneration (AMD) involves retinal pigment epithelium (RPE) dysfunction and has been linked to altered intraocular immunity. Our investigation focuses on immune cell subsets and inflammation-associated factors in the eyes with early and intermediate AMD. We observed elevated levels of activated natural killer (NK) cells and interferon-γ, concurrent with reduced myeloid-derived suppressor cells (MDSCs) and adenosine in AMD eyes. Aqueous humor from AMD patients had diminished ability to dampen NK cell activation, an effect rescued by adenosine supplementation. The

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