Could the inhibition of systemic NLRP3 inflammasome mediate central redox effects of yerba mate? An in silico and pre-clinical translational approach.

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Tác giả: Ana Cristina Andreazza, Djenifer Leticia Ulrich Bick, Catia Santos Branco, Raquel Bridi, Carolina Bordin Davidson, Longaray Ana Paula Delamare, André Flores Dos Santos, Kolinski Alencar Machado, Mirian Salvador, Júlia Maiara Dos Santos, Fernando Joel Scariot, Luciana Touguinha

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Ireland : Journal of ethnopharmacology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 732649

 ETHNOPHARMACOLOGICAL RELEVANCE: Empirically, Ilex paraguariensis A. St. Hil, or yerba-mate, has been used by natives of South America as a stimulant. Nowadays, this plant has gained popularity due to its neuroprotective effects. However, there are few studies on the biochemical-molecular mechanisms of action involved in its effect. AIM OF THE STUDY: Chemically characterize an aqueous extract of yerba mate (YME) and evaluate if it could suppress the aberrant inflammatory response related to neurodegeneration. MATERIALS AND METHODS: Macrophages and microglia cells were exposed to lipopolysaccharide (LPS
  100 ng/mL) plus nigericin (100 μM) or quinolinic acid (QA
  5 mM). Cellular viability, oxidative, and inflammatory markers were evaluated. Chemical matrix (HPLC - DAD), antioxidant activity, safety profile in vitro and in vivo, and an in silico docking of main targets were also assessed. RESULTS: Pre-treatment with YME (15 μg/mL) prevented impairments in redox metabolism and inflammatory markers in BV-2 cells. In macrophages, YME showed similar results to MCC950, an inflammasome inhibitor. YME presented 282.88 mg EAG/g total phenolic content and a redox capacity of 32.94 ± 1.30 μg/mL (IC CONCLUSION: YME has significantly affected macrophages and microglia by regulating the NLRP3 inflammatory pathway.
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