Whole genomic analysis uncovers high genetic diversity of rifampicin-resistant

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Tác giả: Ontlametse T Choga, Wonderful T Choga, Anzaan Dippenaar, Keabetswe Fane, Simani Gaseitsiwe, Botshelo T Kgwaadira, Johannes Loubser, Joseph Makhema, Topo Makhondo, Mpaphi B Mbulawa, Chawangwa Modongo, Tuelo Mogashoa, Tuduetso Molefi, Patience Motshosi, Sikhulile Moyo, Rosemary M Musonda, Justice Tresor Ngom, Dimpho Otukile, Kedumetse Seru, One Stephen, Elizabeth M Streicher, Rob M Warren, Boitumelo Zuze

Ngôn ngữ: eng

Ký hiệu phân loại: 579.135 +Genetics

Thông tin xuất bản: Switzerland : Frontiers in microbiology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 732846

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BACKGROUND: The emergence of drug-resistant METHODS: This study included 202 stored RESULTS: WGS analysis revealed multidrug resistance (57.9%: 95% CI
50.7-64.8), Pre-XDR (16.8%, 95% CI: 11.9-22.7), RR-TB (20.2%: 95% CI: 14.98-26.5), and HR-TB (0.5%, 95% CI
0.01-2.7). We identified a high genetic diversity with three predominant lineages: lineage 4 (60.9%, 95% CI
53.8-67.7), lineage 1 (22.8%: 95% CI
17.2-29.2), and lineage 2 (13.9%, 95% CI: 9.4-19.4). The most frequently observed drug resistance mutations for rifampicin, isoniazid, ethambutol, streptomycin, pyrazinamide, and fluoroquinolones were CONCLUSIONS: This study highlights the high genetic diversity of

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