Association between post-COVID-19 sleep disturbance and neurocognitive function: a comparative study based on propensity score matching.

• Tác giả: Shixu DU, Leqin Fang, Dai Li, Yuanhui Li, Shuai Liu, Xue Luo, Yan Xu, Hangyi Yang, Shufei Zeng, Bin Zhang, Shuqiong Zheng
• Ngôn ngữ: eng
• Thông tin xuất bản: China : Journal of Zhejiang University. Science. B , 2025
• Bộ sưu tập: NCBI
• ID: 733042

Tóm tắt

Despite that sleep disturbance and poor neurocognitive performance are common complaints among coronavirus disease 2019 (COVID-19) survivors, few studies have focused on the effect of post-COVID-19 sleep disturbance (PCSD) on cognitive function. This study aimed to identify the impact of PCSD on neurocognitive function and explore the associated risk factors for the worsening of this condition. This cross-sectional study was conducted via the web-based assessment in Chinese mainland. Neurocognitive function was evaluated by the modified online Integrated Cognitive Assessment (ICA) and the Number Ordering Test (NOT). Propensity score matching (PSM) was utilized to match the confounding factors between individuals with and without PCSD. Univariate analyses were performed to evaluate the effect of PCSD on neurocognitive function. The risk factors associated with worsened neurocognitive performance in PCSD individuals were explored using binary logistic regression. A total of 8692 individuals with COVID-19 diagnosis were selected for this study. Nearly half (48.80%) of the COVID-19 survivors reported sleep disturbance. After matching by PSM, a total of 3977 pairs (7954 individuals in total) were obtained. Univariate analyses revealed that PCSD was related to worse ICA and NOT performance (