The calcineurin-responsive transcription factor Crz1 regulates the expression of CMK2 via a sole CDRE site in its promoter in budding yeast.

• Tác giả: Yiying Gu, Ni Guan, Linghuo Jiang, Yongqiang Jiang, Lijun Meng, Liudan Wei
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 733224

Tóm tắt

 As a yeast homolog of mammalian calcium/calmodulin-dependent protein kinase II (CaMKII), Cmk2 functions as a negative regulator of calcium signaling in Saccharomyces cerevisiae. We show here that the transcription expression of CMK2 is controlled mainly by the transcription factor Crz1 and also by other factor(s) in response to calcium stress. There are four potential binding sites (calcium/calcineurin-dependent responsive elements
  CDREs) for Crz1 in the promoter of CMK2. Through mutational analysis, we demonstrated that mutation of only the site (5' G