Activation of FGFR genes by genetic and epigenetic alterations in uterine leiomyomas.

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Tác giả: Lauri A Aaltonen, Isa Ahlgren, Ralf Bützow, Oskari Heikinheimo, Sini Ilves, Vilja Jokinen, Eevi Kaasinen, Auli Karhu, Riku Katainen, Åsa Kolterud, Helena Kopp Kallner, Kimmo Palin, Annukka Pasanen, Maritta Räisänen, Anniina Raitila, Emma Siili, Aurora Taira, Niko Välimäki

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : BJC reports , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 733236

BACKGROUND: Fibroblast growth factor 1-4 (FGFR1-4) are well-known oncogenic drivers in many cancer types. Here, we studied the role of FGFRs in uterine leiomyoma (UL) that is a benign neoplasm arising from the myometrium and the most common tumour in women. Although ULs can be classified to molecular subtypes based on genetic drivers, potential secondary drivers are not well characterised. METHODS: We performed mutation analysis of RNA-sequencing data of ULs, followed by screening of FGFR alterations in our Finnish (n = 2677) and Swedish (n = 372) UL collections, utilising Sanger-, next-generation and Nanopore sequencing and SNP array data. The role of FGFR genes in UL predisposition was examined by GWAS. RESULTS: We identified FGFR activation in a subset of ULs on both genetic and epigenetic levels. In addition to single-nucleotide mutations in FGFR1/2, we detected an FGFR2-ERC1 fusion gene, FGFR1 gains and hypomethylation of regulatory regions of FGFR2/3. FGFR alterations were enriched in molecularly similar HMGA2, HMGA1 and PLAG1 UL subtypes. We also unveil a UL predisposing variant upstream of FGFR4 associated with increased expression in both normal myometrium and ULs. CONCLUSIONS: Our results establish the role of FGFR signalling in the genesis of UL.
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