Asthma is a chronic respiratory disease that significantly affects children, impacting their health-related quality of life. This study aimed to explore the relationship between asthma control and quality of life among pediatric asthma patients in the West Bank, Palestine. A descriptive, cross-sectional study was conducted among 220 pediatric patients with asthma and their mothers, recruited from four governmental hospitals. Data were collected using self-administered questionnaires that included demographic information, an asthma control test, and the Pediatric Asthma Quality of Life questionnaire. The final analysis included 182 children with a mean age of 8 years. The results showed that 71.9% of the children had uncontrolled asthma, with poor health-related quality of life reported by approximately 70% of this group. In contrast, only 2.7% of children with controlled asthma reported reduced quality of life. The findings indicate a strong association between asthma control and health-related quality of life. Healthcare policies should prioritize educational programs for children and their parents to improve asthma management and overall well-being.