The phenotype of monocyte subtypes and expression of chemokine receptors in the Chronic Venous Insufficiency.

• Tác giả: Jhefferson Miranda Alves, André Luis Lacerda Bachi, Ana Paula Augusto da Cruz Ballerini, Jônatas Bussador do Amaral, Larissa Namie Chiba, Daniela Alves de Abreu, Francisco Antonio Helfenstein Fonseca, Carolina Nunes França, Danielle Borges Germano, Maria Cristina Izar, Luiz Henrique da Silva Nali, Marina Tiemi Shio
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Clinics (Sao Paulo, Brazil) , 2025
• Bộ sưu tập: NCBI
• ID: 733655

Tóm tắt

OBJECTIVE: The aim of this study was to evaluate monocyte subtypes and the chemokine receptors, comparing individuals with and without Chronic Venous Insufficiency (CVI). METHOD: The authors included patients undergoing surgery for varicose veins of the lower limbs (Classification of Venous Disorders - CEAP: C1‒C3). RESULTS: There were increased levels of classical and non-classical monocytes in the case group and a reduction in intermediate monocytes. Besides, there was higher expression of CCR5 in the non-classical monocytes and lower expression of CX3CR1 in the classical monocytes in the case group. CONCLUSIONS: The inflammatory process present in patients with CVI can modulate the monocyte phenotype and the expression of the chemokine receptors at the protein level.