Novel mechanistic insights into the comorbidity of anemia and rheumatoid arthritis: Identification of therapeutic targets.

• Tác giả: Shou Chen, Cun Li, Xiaoming Peng, Xiongzhi Shi, Shaohui Zong
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Molecular immunology , 2025
• Bộ sưu tập: NCBI
• ID: 733677

Tóm tắt

OBJECTIVES: To investigate the mechanisms underlying the comorbidity of anemia and rheumatoid arthritis (RA) and identify promising therapeutic targets. METHODS: We assessed the phenotypic linkage between anemia and RA. Using the largest genome-wide association studies (GWAS) summary statistics of European populations, we scrutinized the causal association and shared genetic architecture between the two conditions using multiple complementary approaches. RESULTS: Logistic regression analysis confirmed a strong clinical association between anemia and RA. Using GWAS data, we identified a significant causal effect of RA on anemia and positive global genetic correlations between the two conditions (r CONCLUSIONS: This study provides novel insights into anemia-RA comorbidity mechanisms and identifies new drug targets for RA.