Uranium (U(VI)) has chemical and radiological toxicity, so the effective treatment of uranium-containing wastewater is crucial for both environmental safety and human health. Here, a carbon nanosphere (CNS) supported hydroxyapatite (HAP) nanorod (HAP/CNS) adsorbent was prepared using a simple glucose-assisted hydrothermal method toeffectively immobilize U(VI). Glucose not only derived CNS, but also facilitated HAP crystallization, prohibited HAP aggregation, and introduced oxygen-containing functional groups (i.e., COOH). The optimized HAP/CNS possessed a fantastic adsorption capability of 3080.3 mg/g for U(VI), nearly three times that of HAP and much higher than many reported HAP-based adsorbents. Notably, HAP/CNS was less affected by coexisting ions (distribution coefficient, K