Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis.

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Tác giả: Georgios Amanakis, Federico Armando, Wolfgang Baumgärtner, Georg Beythien, Małgorzata Ciurkiewicz, Sabrina Clever, Robert Geffers, Katharina Manuela Gregor, Carina Gross, Timo Henneck, Laura Heydemann, Kirsten Hülskötter, Mika K Kaneko, Yukinari Kato, Christian Meyer Zu Natrup, Lukas Mathias Michaely, Andreas Pavlou, Wencke Reineking, Karl Rohn, Dirk Schaudien, Tom Schreiner, Klaus Schughart, Lisa-Marie Schünemann, Theresa Störk, Tamara Tuchel, Asisa Volz, Maren von Köckritz-Blickwede, Isabel Zdora

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Nature communications , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 733985

Long-term consequences of SARS-CoV-2 infection affect millions of people and strain public health systems. The underlying pathomechanisms remain unclear, necessitating further research in appropriate animal models. This study aimed to characterize the trajectory of lung regeneration over 112 days in the male hamster model by combining morphological, transcriptomic and functional readouts. We demonstrate that in the acute phase, SARS-CoV-2 Delta-infected, male, aged hamsters show a severe impairment of lung function at rest. In the chronic phase, similar impairments persisted up to 7 weeks post-infection but were only evident after exercise on a rodent treadmill. The male hamster model recapitulates chronic pulmonary fibrotic changes observed in many patients with respiratory long COVID, but lacks extra-pulmonary long-term lesions. We show that sub-pleural and interstitial pulmonary fibrosis as well as alveolar bronchiolization persist until 112 dpi. Interestingly, CK8
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