HBV-associated hepatocellular carcinomas inhibit antitumor CD8

• Tác giả: Runsheng Chen, Shu-Qun Cheng, Xiang Ding, Chengzhi Du, Yanan Gao, Yajing Hao, Xuetao Huang, Nan Li, Jianjun Luo, Kang Wang, Fuquan Yang, Pengyuan Yang, Maojun You, Zhenxing Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 734019

Tóm tắt

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Extracellular vesicles (EV) are critical mediators of intercellular communication within the tumor microenvironment, and cancer-cell-secreted EVs often facilitate cancer progression. Here we show that in HBV-associated HCC, tumor-cell-derived EVs contain a TGFβ-inducible long noncoding RNA, termed HDAC2-AS2. EVs enriched with HDAC2-AS2 facilitate cancer progression by suppressing cytotoxicity of intra-tumor CD8