Esketamine induces embryonic and cardiac malformation through regulating the nkx2.5 and gata4 in zebrafish.

• Tác giả: Huansen Huang, Tingyu Jiang, Shuang Li, Xiang Li, Qiuyun Ou, Jiancheng Tang, Rui Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 734271

Tóm tắt

Esketamine (EK) has been widely used in the treatment of depression, but the effects of EK prenatal treatment on embryonic heart development have been rarely reported. This study assesses the effects of varying concentrations of EK on embryonic development and cardiogenesis to determine the teratogenic concentration in the zebrafish model, centering on the interaction between the genes nkx2.5 and gata4 to elucidate the mechanisms underlying cardiac morphogenesis. Zebrafish embryos were classified into six distinct groups and exposed to either a vehicle or EK to ascertain the median lethal concentration (LC