Enterocloster clostridioformis protects against Salmonella pathogenesis and modulates epithelial and mucosal immune function.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Benjamin S Beresford-Jones, Simon Clare, Katherine Harcourt, Trevor D Lawley, Junhee Lee, Virginia A Pedicord, Puspendu Sardar, Amelia Soderholm, Satoshi Suyama, Wangmingyu Xia

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Microbiome , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 734558

 BACKGROUND: Promoting resistance to enteric pathogen infection is a core function of the gut microbiota
  however, many of the specific host-commensal interactions that mediate this protection remain uncharacterised. To address this knowledge gap, we monocolonised germ-free mice with mouse-derived commensal microbes to screen for microbiota-induced resistance to Salmonella Typhimurium infection. RESULTS: We identified Enterocloster clostridioformis as a protective species against S. Typhimurium infection. E. clostridioformis selectively upregulates resistin-like molecule β and cell cycle pathway expression at the level of caecal epithelial cells and increases T-regulatory cells in the underlying mucosal immune system, potentially contributing to reduced infection-induced pathology. CONCLUSIONS: We highlight novel mechanisms of host-microbe interactions that can mediate microbiota-induced resistance to acute salmonellosis. In the backdrop of increasing antibiotic resistance, this study identifies novel potential avenues for further research into protective host responses against enteric infections and could lead to new therapeutic approaches. Video Abstract.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH