Cerebral Venous Thrombosis and Nitrous Oxide Intoxication: Report of Two Cases and Review of the Literature.

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Tác giả: Agnes Aghetti, Isabelle Crassard, Maxime Delrue, Diana Doukhi, Stéphanie Guey, Mikael Mazighi, Peggy Reiner, Virginie Siguret, Dominique Vodovar

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Brain and behavior , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 734640

BACKGROUND: Cerebral venous thrombosis (CVT) has various risk factors, including contraception, pregnancy, neoplasia, and thrombophilia. Nitrous oxide (N₂O), historically used as an anesthetic and more recently as a recreational drug, has been associated with neurological complications such as myeloneuropathy and thromboembolic events. Here, we report two cases of CVT associated with N₂O use and provide a review of the literature on this association. METHODS: We describe two local cases of CVT associated with N RESULTS: Among the 12 patients, seven had co-existing CVT risk factors. Most patients reported chronic N CONCLUSIONS: These cases highlight an emerging association between CVT and N₂O use. Prompt recognition of this link is critical to recommend cessation of N₂O use, alongside anticoagulation therapy and consideration of vitamin supplementation to prevent complications and recurrence.
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