Assembly of thioether analogs from 2-mercaptobenzoxazole-fused honokiol and heterocyclic scaffolds and evaluation of their agrochemical potential.

• Tác giả: Jin-Qiu Duan, Ming-Tao He, Qiang Hu, Jing Liang, Chun Yang, Zhen-Zhen Zheng, Xiao-Yan Zhi
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Pest management science , 2025
• Bộ sưu tập: NCBI
• ID: 734858

Tóm tắt

BACKGROUND: Persistent and excessive application of conventional synthetic pesticides has triggered a series of environmental and agricultural product safety risks in recent decades. Natural products are considered to provide considerable sources for the innovation of novel ecofriendly agrochemicals with high efficacy. RESULTS: In this work, a structural splicing strategy was used to prepare 37 honokiol-derived thioether analogs bearing different heterocyclic scaffolds and their pesticidal activities were assessed. Bioassay results showed that most of the target compounds have growth inhibitory activity against Mythimna separata. Notably, compounds I1 and I2 showed prominent growth inhibitory activity against M. separata with 50% lethal concentration (LC CONCLUSION: The novel scaffolds and remarkable insecticidal potency position the honokiol-based analogs reported herein as promising candidate leads for further development as agrochemicals for pest management. © 2025 Society of Chemical Industry.