The side effects of chemotherapy drugs have prompted the development of targeted therapies. Distinctive abundance of lipid peroxidation (LPO) in tumor cells represents a potential target for drug delivery. However, LPO - based targeted ligands remain under - exploited. In this work, the targeting of 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO), was investigated within a mesoporous silica nanocarrier loaded with doxorubicin (DOX) and connected with 4-NH