Lysosome-Targeting Chimera Using Mannose-6-Phosphate Glycans Derived from Glyco-Engineered Yeast.

• Tác giả: Danbi An, Jiyeon Kang, Seobin Kim, Doo-Byoung Oh, Jinho Seo
• Ngôn ngữ: eng
• Ký hiệu phân loại: 381.195 t Garage, rummage, and related sales
• Thông tin xuất bản: United States : Bioconjugate chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 735010
• Chủ đề: 1. Lysosome; 2. Targeting; 3. Chimera

Tóm tắt

Lysosome-targeting chimeras (LYTACs) harness the cell's lysosomal degradation machinery to break down extracellular and membrane proteins. Previous methods used a synthetic glycopeptide containing multiple serine-O-mannose-6-phosphate (poly-M6Pn), which presented challenges such as synthetic complexity and potential immunogenicity associated with poly-M6Pn. This study introduced a LYTAC formulation, LYTAC