BACKGROUND: This study determined, implemented, and assessed a nurse-led radical cystectomy follow-up protocol. METHODS: In 2021, an evidence-based risk-stratified protocol (non-urological cancers and benign [N-UC&B], low, or high risk) was developed from current guidelines, local and national expert opinion, and after formal discussion with the Urological Society of Australia and New Zealand (USANZ) Western Australia (WA) and Australia and New Zealand Urogenital and Prostate (ANZUP) Cancer Trials Group. Retrospective and prospective assessment of cystectomy follow-up occurred between 2015 and 2023. Patients received 'surgeon-led' follow-up March 2015 to August 2021, and 'nurse-led' follow-up August 2021 to April 2023. Adherence to follow-up, cost-analysis, and healthcare efficiency calculations were performed. RESULTS: Of 176 cystectomy patients, 159 (90.3%) were eligible for inclusion. Overall adherence to nurse-led follow-up was 78.6% compared to 43.4% in surgeon-led (P <
0.002). Adherence to nurse-led follow-up was higher in all risk categories (high-risk 79.1% vs. 43%, P <
0.002
low risk 75% vs. 52.3%, P = 0.110
N-UC&B 71% vs. 30%, P = 0.153). Nurse-led consultation saved 9.50 per consultation with overall cost savings of 79.50, 16.50, and 95 for the entire follow-up period for N-UC&B, low, and high-risk groups based on consultation alone. A total of 1072 appointments (536 h, 2 390.40) would have been saved if the surgeon-led cohort of patients were seen in nurse-led clinics. CONCLUSION: Protocol driven nurse-led cystectomy follow-up demonstrates excellent adherence and may be more cost-effective than surgeon-led follow-up.