Histone Deacetylases in Metabolism: the Known and the Unexplored.

• Tác giả: Rushita A Bagchi, Jayden Carter, Somaya Y Ibrahim
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Physiology (Bethesda, Md.) , 2025
• Bộ sưu tập: NCBI
• ID: 735988

Tóm tắt

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from key lysine residues on histone and nonhistone proteins and thereby regulate gene transcription. They have been implicated in several biological processes in both healthy and pathological settings. This review discusses the role of HDACs in multiple metabolically active tissues and highlights their contribution to the pathogenesis of tissue-specific maladaptation and diseases. We also summarize the current knowledge gaps and potential ways to address them in future studies.