Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor.

• Tác giả: Qi-Yue Chen, Sanny S W Chung, Christopher B Damoci, Yinshan Fang, Tala Fnu, Yuefeng Huang, Chao Lu, Jianwen Que, Anjali Saqi, Peiguo Shi, Timothy C Wang, Xuebing Wu, Dian Yang, Wanwei Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Cancer discovery , 2025
• Bộ sưu tập: NCBI
• ID: 736080

Tóm tắt

SCLC is highly aggressive, with limited effective treatment options. We show that ablating sympathetic nerves or inhibiting the ADRB2 receptor slows SCLC progression and prolongs survival in mice. Additionally, ADRB2 inhibition reduces the growth of human SCLC organoids and xenografts by disrupting PKA signaling, identifying a new therapeutic target.