Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Loaded Mir-29-3p Targets AhR to Improve Juvenile Idiopathic Arthritis via Inhibiting the Expression of IL-22 in CD4

• Tác giả: Zhi Chen, Qin Cheng, Xiao Du, Yu Fang, Meilin He, JingWei Li, Sha Li, Yuanyuan Peng, Kunpeng Sui, Haiming Tang, Xinyi Wei, QiuYue Wen, Xue Xie, Wei Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Stem cell reviews and reports , 2025
• Bộ sưu tập: NCBI
• ID: 736306

Tóm tắt

BACKGROUND: Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children. Human umbilical cord mesenchymal stem cells (HUCMSCs)-derived exosomes (HUCMSCs-Exos) are involved in autoimmune diseases. This study investigates the mechanism of HUCMSC-Exos in improving JIA by targeting AhR through delivery of miR-29-3p to inhibit IL-22 expression in CD4 METHODS: Collagen induced arthritis (CIA) mouse model was established, and mice were treated with HUCMSCs-Exos and miR-29-3p antagomir, respectively. CD4 RESULT: JIA-CD4 CONCLUSION: HUCMSCs-Exos loaded miR-29-3p targets AhR to improve JIA via inhibiting the expression of IL-22 in CD4