Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer.

• Tác giả: Alan Ashworth, Michelle L Badura, Andries M Bergman, Megha Bhalla, William S Chen, Lisa N Chesner, Matthew R Cooperberg, Rajdeep Das, Charles G Drake, Felix Y Feng, Lawrence Fong, Adam Foye, Luke A Gilbert, Julie N Graff, Xiangnan Guan, Reed M Hawkins, Jessica E Hawley, Ya-Mei Hu, Junjie T Hua, Lisa M Kim, Duygu Kuzuoglu-Ozturk, Haolong Li, Simon Linder, Arian Lundberg, Amy E Moran, Thomas O'loughlin, Fanny Polesso, David A Quigley, Davide Ruggero, Tanushree Shenoy, Raunak Shrestha, Martin Sjöström, Alexis K Smith, Adam G Sowalsky, Shana Y Trostel, Scott Wilkinson, Zheng Xia, Faming Zhao, Xiaolin Zhu, Wilbert Zwart
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Cancer discovery , 2025
• Bộ sưu tập: NCBI
• ID: 736389

Tóm tắt

Immunotherapy options for immune cold tumors, like prostate cancer, are limited. We show that AR downregulates MHCI expression/antigen presentation and that AR inhibition improves T-cell responses and tumor control. This suggests that treatments combining AR inhibitors and checkpoint blockade may improve tumor immune surveillance and antitumor immunity in patients.