The advent of bionic skin sensors represents a significant leap forward in the realm of wearable health monitoring technologies. Existing bionic skin technologies face several limitations, including complex and expensive manufacturing processes, low wearing comfort, and challenges in achieving comfortable real-time health monitoring. These shortcomings hinder the widespread adoption and practical utility of bionic skin in various applications. The bionic skin invention presented in this article addresses these issues by introducing a novel thermal transfer manufacturing process that is low-cost and easy to operate. This method is particularly suitable for the small-scale mass production required for bionic skin applications. Additionally, the innovative bilayer unidirectional moisture transport nanomembrane incorporated into the bionic skin offers high extensibility and breathability. This feature enhances the ability of the skin to absorb sweat, thereby facilitating comfortable real-time health monitoring. The specially designed bionic skin sensor embedded within this system can monitor various biomarkers in sweat, including glucose, lactic acid, uric acid, pH, temperature, and skin impedance. When combined with the CARE(Continuous Analyte Monitoring with Real-time Engagement) system, it enables real-time data transmission and processing, offering a comprehensive approach to health monitoring that is both comfortable and reliable.