BCL6 Promotes Transcription of GPR61 to Suppress IL-1β-Induced Osteoarthritis Progression in C28/I2 Cells.

• Tác giả: Gang Deng, Zhengnan Li, Yizhou Xu, Guangxuan Zeng
• Ngôn ngữ: eng
• Thông tin xuất bản: Australia : Microbiology and immunology , 2025
• Bộ sưu tập: NCBI
• ID: 736612

Tóm tắt

Osteoarthritis (OA) is the most common joint disease and its pathogenic mechanism remains to be ensured. This study focused on the regulatory relation between B-cell lymphoma 6 (BCL6) and G-protein-coupled receptor 61 (GPR61) underlying IL-1β in OA. Real-time quantitative polymerase chain reaction and western blot were performed for mRNA and protein detection. Oxidative injury was assessed by reactive oxygen species (ROS), malondialdehyde (MDA), and glutathione (GSH) via kits. Fe