Studies on the Stereoselective Synthesis of Sacubitril via a Chiral Amine Transfer Approach.

• Tác giả: Rajesh G Gonnade, Ravindar Kontham, Megha V Sadanande, Himanshu Sharma, Geetika Singh, Sagar S Thorat, Kumar Vanka
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Chemistry, an Asian journal , 2025
• Bộ sưu tập: NCBI
• ID: 736622

Tóm tắt

We present a comprehensive account of our efforts directed towards the synthesis of sacubitril, a neprilysin inhibitor used in combination with valsartan and marketed as Entresto™. Our initial approach to the formal synthesis of sacubitril employed a chiral pool strategy, utilizing (S)-pyroglutamic acid as a key building block and Cu(I)-mediated Csp