Cannabis Use Cessation and the Risk of Psychotic Disorders: A Case-Control Analysis from the First Episode Case-Control EU-GEI WP2 Study: L'arrêt de l'utilisation du cannabis et le risque de troubles psychotiques: Une analyse cas-témoins tirée de l'étude cas-témoins EU-GEI WP2 centrée sur les premiers épisodes psychotiques.

• Tác giả: Celso Arango, Isabelle Austin-Zimmerman, Miquel Bernardo, Julio Bobes, Benjamin W Bond, Edward Chesney, Lieuwe de Haan, Cristina Marta Del-Ben, Marta Di Forti, Bea Duric, Laura Ferraro, Tom P Freeman, Charlotte Gayer-Anderson, Caterina La Cascia, Zhikun Li, Paulo Rossi Menezes, Robin M Murray, Baptiste Pignon, Diego Quattrone, Victoria Rodriguez, Bart P F Rutten, Franck Schürhoff, Jean-Paul Selten, Edoardo Spinazzola, Simona Stilo, Andrei Szöke, Ilaria Tarricone, Giada Tripoli, Giulia Trotta, Evangelos Vassos
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Canadian journal of psychiatry. Revue canadienne de psychiatrie , 2025
• Bộ sưu tập: NCBI
• ID: 737053

Tóm tắt

 OBJECTIVES: To establish whether the risk of psychotic disorders in cannabis users changes with time following cannabis cessation using data from the European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI) case-control study. METHODS: The EU-GEI case-control study collected data from first episode psychosis patients and population controls across sites in Europe and Brazil between May 2010 and April 2015. Adjusted logistic regressions were applied to examine whether the odd of psychosis case status changed: (1) with time following cannabis cessation and (2) across different cannabis use groups. RESULTS: Psychosis risk declined following cessation of cannabis use (β = -0.002
  95% CI -0.004 to 0.000
  CONCLUSION: Risk of psychotic disorder appears to decline with time following cannabis cessation, receding to that of those who have never used cannabis after 37 weeks or more of abstinence. Although, preliminary results suggest that frequent users of high potency types of cannabis might maintain an elevated risk compared to never users even when abstaining for longer than 181 weeks.