Osteoarthritis is a major health problem due to its high prevalence. It is a very common cause of consultation in both primary care and hospitals, implying a high care burden and health costs. Current treatment recommendations are based on a conservative approach, based mainly on physical exercise and ultimately on prosthetic surgery. Between both therapeutic measures there is a wide range of interventional possibilities with disparate evidence, aimed at patients in whom medical treatment does not achieve sufficient symptomatic control and their osteoarthritis is not indicated for surgery. Due to the observed need for analysis and summary of knowledge in this field, and as a result of this forum of experts, this guide has been developed to help decision-making on some areas of gloom that we find in daily clinical practice for the interventional therapeutic approach to gonarthrosis.