Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review.

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Tác giả: Liangliang Cheng, Jianchen Guan, Yuchen Liu, Yunzhuan Luo, Kaiming Ma, Xing Qiu, Linbao Wang, Jiawei Ying, Dewei Zhao

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Australia : Orthopaedic surgery , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 737231

Traumatic osteonecrosis of the femoral head (TONFH) refers to ischemic osteonecrosis is resulting from an acute mechanical interruption of the blood supply to the femoral head. The early diagnosis and optimal treatment have been central focuses of research and continue to undergo improvement. Reliable animal models are essential for advancing research into the treatment of the disease. This review aims to provide a comprehensive overview of tetrapod models (rats, rabbits, dogs, and sheep) and bipod models (emus, ostriches), as well as various modeling methods (traumatic hip dislocation, dissection of the round ligament and ligature of the femoral neck, femoral neck fracture (FNF), reduction and internal fixation after femoral neck fracture, and highly selective disruption of the anterior-superior retinacular vessels). This review examines the advantages, disadvantages, and applicability of each model. Based on blood flow analysis, it proposes a more reliable direction for TONFH modeling: simulating partial blood flow injury in the context of FNF.
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