Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer.

• Tác giả: Yawen Gao, Hong Huang, Yupeng Jiang, Yuyao Liu, Tiantian Zhao, Zengyi Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Cancer immunology, immunotherapy : CII , 2025
• Bộ sưu tập: NCBI
• ID: 737531

Tóm tắt

 PURPOSE: Microsatellite high instability/deficient mismatch repair (MSI-H/dMMR) colorectal cancer (CRC) has an active tumor microenvironment, rendering it more sensitive to immune checkpoint inhibitors. Given that studies involving patients with MSI-H colorectal cancer with RAS mutations are scarce, we explored the effect of RAS mutations on the TME in patients with MSI-H/dMMR cancer and identified potential prognostic factors. METHODS: Seventy-five patients diagnosed with MSI-H/dMMR colorectal cancer were retrospectively enrolled and divided into RAS-mutant and -wild-type groups. The expression levels of CD11c RESULTS: RAS-mutant MSI-H colorectal patients were more likely to have: (1) higher platelet values
  (2) shorter disease-free survival (DFS)
  (3) lower infiltrated numbers of CD11c CONCLUSION: RAS mutations in patients with MSI-H/dMMR CRC may reduce the infiltration of CD11c