Elevated SAMD3 expression in T cells predicts improved survival in pancreatic ductal adenocarcinoma patients.

• Tác giả: Bokang Cui, Lingyi Fu, Shuo Li, Ziteng Li, Lang Tian, Liyan Wu, Enliang Zhou, Xinxin Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Cancer immunology, immunotherapy : CII , 2025
• Bộ sưu tập: NCBI
• ID: 737541

Tóm tắt

OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) has an immune-suppressive tumor microenvironment that contributes to resistance to immunotherapy. This study aimed to demonstrate that elevated sterile alpha motif domain-containing protein 3 (SAMD3) expression in effector CD8 DESIGN: We investigated the heterogeneity and gene expression profiles of T cells using a single-cell RNA sequencing (sc-RNA-seq) dataset comprised of human PDAC samples. SAMD3 mRNA expression was further evaluated in a tumor-specific OT-I/ovalbumin (OVA) mouse model. SAMD3 levels and their clinical significance were evaluated via immunohistochemistry (IHC) analysis. RESULTS: SAMD3 was highly expressed in cytotoxic CD8 CONCLUSION: SAMD3 is a biomarker of T cell function, with elevated expression in T cells predicting improved survival. These findings highlight the potential of precision immunotherapy approaches for treating PDAC.