This review provides a comprehensive exploration of how artificial intelligence (AI) is reshaping medical education and the role of traditional textbooks. The historical context underscores the evolution of medical knowledge bridging past advances with current AI-driven innovations, highlighting the indispensable role of both printed and electronic medical textbooks. The strengths and limitations of traditional and digital textbooks are considered. The potential for AI to enhance medical education through real-time updates, personalized learning, and advanced visual aids is particularly compelling. This perspective is critical for practitioners and educators who are navigating the integration of AI in their fields.