Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK.

• Tác giả: Xiangguo Che, Je-Yong Choi, Poo-Reum Choi, Ying Cui, Keun Hur, Xian Jin, Hyun-Ju Kim, Dong-Kyo Lee, Sihoon Lee
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Experimental & molecular medicine , 2025
• Bộ sưu tập: NCBI
• ID: 737606

Tóm tắt

 Phospholipase C β (PLCβ) is involved in diverse biological processes, including inflammatory responses and neurogenesis
  however, its role in bone cell function is largely unknown. Among the PLCβ isoforms (β1-β4), we found that PLCβ4 was the most highly upregulated during osteoclastogenesis. Here we used global knockout and osteoclast lineage-specific PLCβ4 conditional knockout (LysM-PLCβ4