OBJECTIVE: To characterize trends and outcomes with fenestrated and branched endovascular aortic repair (F/B-EVAR) performed at centers participating in the US Aortic Research Consortium. METHODS: F/B-EVARs performed in 10 prospective, nonrandomized, physician-sponsored investigative device exemption studies from 2015 to 2023 were studied retrospectively. Outcomes included 30-day major adverse event (MAE) and 1-year secondary reintervention. Outcome determinants were modeled with mixed effects multivariable regression. Adjusted observed minus expected cumulative sum analysis was used to evaluate outcomes achieved over time. RESULTS: In the study period, 2377 patients underwent F/B-EVAR. The median follow-up was 2.3 years (interquartile range [IQR], 0.7-3.5 years). The proportion of thoracoabdominal aneurysms (P = .01) and aortic dissections (P = .002) increased over the study period while technical failure rates (P = .6) and length of hospital stay (P = .1) remained stable. Fusion imaging (P = .0005), low-profile devices (P <
.0002), and completely transfemoral repair (P = .0005) were adopted increasingly over time. There were decreases in fluoroscopy time, procedure time, radiation dosage, and blood loss throughout the study (all P <
.0002). Adjusted 30-day survival was 99.6% (IQR, 99.3%-99.8%) and MAE occurred in 240 (10%). MAE determinants included age (odds ratio [OR], 1.3 per 10-years
95% confidence interval [CI], 1.1-1.6
P = .005), estimated glomerular filtration rate (OR, 0.9 per 10-mL/min/1.73 m CONCLUSIONS: Data from multiple US centers demonstrate that F/B-EVAR can be performed safely and with acceptable outcomes. Despite increasing repair extent and complexity, the rates of technical failure, adverse events, and reintervention remained stable, likely driven, in part, by evolutions in minimally invasive techniques.