Chidamide functions as a VISTA/PSGL-1 blocker for cancer immunotherapy.

• Tác giả: Qingyu Dong, Yanfeng Gao, Zhuoying He, Wanqiong Li, Feiyu Luo, Tao Luo, Xiaoshuang Niu, Wenzhi Shang, Xinghua Sui, Yixuan Sun, Youmei Xiao, Xin Yang, Wenshan Zhao, Xiuman Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Cancer immunology, immunotherapy : CII , 2025
• Bộ sưu tập: NCBI
• ID: 737930

Tóm tắt

The response rates of PD-1/PD-L1 blockade in cancer immunotherapy are relatively low, necessitating the development of novel immune checkpoint inhibitors. Compared with other immune checkpoints, VISTA interacts with its ligand PSGL-1 only under acidic conditions in the tumor microenvironment to suppress the function of CD8