Ibogalogs decrease neuropathic pain in mice through a mechanism involving crosstalk between 5-HT

• Tác giả: Hugo R Arias, Lorenzo Di Cesare Mannelli, Sonya Galant, Carla Ghelardini, Anders A Jensen, Dina Manetti, Philippe Marin, Laura Micheli, Maria Novella Romanelli, Franck Vandermoere, Daniel Venturi
• Ngôn ngữ: eng
• Thông tin xuất bản: France : Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie , 2025
• Bộ sưu tập: NCBI
• ID: 737969

Tóm tắt

The objective of this study was to determine the anti-neuropathic activity of a variety of ibogalogs, including tabernanthalog (TBG), ibogaminalog (DM506), ibogainalog (IBG), nor-IBG, catharanthalog (CAG), and PNU-22394 using the oxaliplatin (OXA) neuropathic pain model in mice, and to investigate whether there is crosstalk between the 5-HT