To translate and adapt the English version of the Caregiver Contributions to Self-Care of Heart Failure Index (CC-SCHFI) to Chinese, and further to investigate the psychometric properties of the Chinese version of CC-SCHFI in a cohort of caregivers of people with heart failure. CC-SCHFI translation and cross-cultural adaption were performed. 240 caregivers were recruited to complete the instrument. The internal construct reliability was evaluated by Cronbach's α and item-to-total correlations. The concurrent validity was tested by using the CACHS which also measures caregivers' contribution to HF self-care. Psychometric analysis was performed with confirmatory factor analysis (CFA). We evaluated 4-factor structure for caregiver contribution to self-care maintenance scale, 1-factor structure for caregiver contribution to self-care management scale and 2-factor structure for confidence in contributing to self-care scale. All the subjects successfully completed the interviews in an average of 12.3 ± 3.2 min. The internal consistency reliability analysis of the CC-SCHFI showed Cronbach α of 0.83. All items showed adequate discrimination, with the item-total correlation coefficient of greater than 0.4. The scores of CC-SCHFI scales were significantly correlated with the CACHS scale scores. The correlation coefficients ranged from 0.341 to 0.765, indicating acceptable concurrent validity. For CFA, all factor loadings were significant at >
0.30 and generally medium to high. The simplified Chinese version of CC-SCHFI is a psychometrically reliable instrument with empirically supported validity, which can be applied to clinical evaluation of the contribution of caregivers to HF self-care. Compared with CACHS, CC-SCHFI can be more easily completed and simultaneously maintains acceptable concurrent validity. Further studies are warranted to investigate the combined use of these two instruments among other populations.