Endothelial cell Pannexin1 overexpression impairs ischemic stroke outcome in a sex-dependent manner.

• Tác giả: Eric Y Dai, Colleen K Duffy, Miranda E Good, Brant E Isakson, Amanda K Mauro, Christopher B Medina, Kodi S Ravichandran, Guleer Shahab, Maria Tomàs-Gracia
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 738361

Tóm tắt

Ischemic stroke is a leading cause of morbidity and mortality. We have previously shown that deletion of endothelial cell (EC) Panx1 reduces ischemic stroke infarct volume and reduces cerebral arterial myogenic reactivity, which regulates cerebral blood flow. We hypothesized that EC Panx1 content dictates ischemic stroke outcome and thus increased EC Panx1 expression will worsen ischemic stroke outcomes due to exacerbated myogenic tone development and impaired cerebral blood flow recovery. To test this, we generated the Cdh5-Cre