Centromeres in the thermotolerant yeast

• Tác giả: Charles L Asbury, Daniel J Barrero, Sue Biggins, Sabrine Hedouin, Yizi Mao, Eileen O'Toole, Andrew Stergachis
• Ngôn ngữ: eng
• Ký hiệu phân loại: 515.243 Series
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 738377

Tóm tắt

Eukaryotic chromosome segregation requires spindle microtubules to attach to chromosomes through kinetochores. The chromosomal locus that mediates kinetochore assembly is the centromere and is epigenetically specified in most organisms by a centromeric histone H3 variant called CENP-A. An exception to this is budding yeast which have short, sequenced-defined point centromeres. In