Cerebellar climbing fibers convey perceptual choice during decision-making.

• Tác giả: Lei Ma, Maozhen Qin, Evan A Wilson, Takaki Yahiro, Tin Long Yiu, Haining Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 621.3815322 Electrical, magnetic, optical, communications, computer engineering; electronics, lighting
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 738381
• Chủ đề: 1. Cerebellar; 2. Climbing; 3. Fibers

Tóm tắt

Cerebellar climbing fibers are thought to signal reward prediction errors in non-motor functions. By imaging postsynaptic responses of climbing fibers onto mouse Purkinje cell dendrites during auditory discrimination, we found that climbing fibers in crus I can encode cue identities or perceptual choices. These responses were reshaped by reversal learning. Optogenetic perturbation of climbing fiber activity impaired discrimination. These results suggest a feedforward role of climbing fibers in perceptual decision-making.