Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system.

• Tác giả: Igor Antoshechkin, Raffi V Aroian, Jeffrey D Chicca, Carli Garceau, E Jane Homan, Vladislav Ilík, Hanchen Li, Jason B Noon, Gary R Ostroff, Barbora Pafčo, Erich M Schwarz, Amy M Weeks
• Ngôn ngữ: eng
• Ký hiệu phân loại: 328.33455 Specific topics of legislative bodies
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 738384
• Chủ đề: 1. Hookworm; 2. Genes; 3. Encoding

Tóm tắt

Hookworms are intestinal parasitic nematodes that chronically infect ~500 million people, with reinfection common even after clearance by drugs. How infecting hookworms successfully overcome host protective mechanisms is unclear, but it may involve hookworm proteins that digest host tissues, or counteract the host's immune system, or both. To find such proteins in the zoonotic hookworm