Muscle macrophage regenerative response after squalene-adjuvanted influenza vaccination drives Th2-skewed response and is reduced with age.

• Tác giả: Eleanor Burgess, Lauren A Chang, Lynda Coughlan, Juan Garcia-Bernalt Diego, Farah El Ayache, Leonie Gruneberg, Kaijun Jiang, Gabriel Laghlali, Jorge Levican, Haye Nijhuis, Moataz Noureddine, Seokchan Park, Michael Schotsaert, Prajakta Warang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 296.1135 Sources
• Thông tin xuất bản: United States : Research square , 2025
• Bộ sưu tập: NCBI
• ID: 738443

Tóm tắt

Squalene-based adjuvants like MF59, and its research alternative AddaVax, induce transient muscle injury, but their working mechanisms downstream of muscle injury remain unclear. We show that an AddaVax-adjuvanted quadrivalent inactivated influenza virus vaccine (QIV) intramuscular injection triggers muscle regeneration-like immune processes and increases CX3CR1